Research Papers

Explore our latest research findings and publications.

Full list

2024

eEF2K regulates pain through translational control of BDNF

Patrick R. Smith, Guadelupe Garcia, Angela R. Meyer, Alexey G. Ryazanov, Tao Ma, Sarah Loerch, and Zachary Campbell

Molecular Cell Dec 14:S1097-2765(24)00948-1

doi:10.1016/j.molcell.2024.11.023

2023

Protocol for the isolation and culture of mouse dorsal root ganglion neurons for imaging applications

Patrick R Smith, Angela Meyer, Sarah Loerch, Zachary T Campbell

STAR Protocols (2023) Dec 15;4(4):102717

doi:10.1016/j.xpro.2023.102717

2022

Recent advances and current trends in cryo-electron microscopy

Marghe Guaita, Scott C. Watters, and Sarah Loerch

Current Opinion in Structural Biology (2022) Dec:77:102484

doi: 10.1016/j.sbi.2022.102484

In situ single particle classification reveals distinct 60S maturation intermediates in cells

Bronwyn A Lucas, Kexin Zhang, Sarah Loerch, and Niko Grigorieff

Elife (2022) Aug 25:11:e79272

doi: 10.7554/eLife.79272

A UHM-ULM interface with unusual structural features contributes to U2AF2 and SF3B1 association for pre-mRNA splicing

Justin W Galardi , Victoria N Bela, Nazish Jeffery, Xueyang He, Eliezra Glasser, Sarah Loerch, Jermaine L Jenkins, Mary J Pulvino, Paul L Boutz, Clara L Kielkopf

J. Biol. Chem. (2022) Aug;198(8):102224

doi: 10.1016/j.jbc.2022.102224

Identifying Inhibitors of −1 Programmed Ribosomal Frameshifting in a Broad Spectrum of Coronaviruses

Sneha Munshi, Krishna Neupane, Sandaru M Ileperuma, Matthew T J Halma , Jamie A Kelly, Clarissa F Halpern, Jonathan D Dinman, Sarah Loerch, Michael T Woodside

Viruses (2022) Jan 18;14(2):177

doi: 10.3390/v14020177

The space between notes: emerging roles for translationally silent ribosomes

PR Smith, SC Pandit, S Loerch, ZT Campbell

Trends Biochem Sci (2022) Jun;47(6):477-491

doi: 10.1016/j.tibs.2022.02.003.

2021

Functionally distinct roles for eEF2K in the control of ribosome availability and P-body abundance

Patrick R. Smith, Sarah Loerch, Nikesh Kunder, Alexander D. Stanowick, Tzu-Fang Lou & Zachary T. Campbell

Nature Communications (2021) Nov 23;12(1):6789

doi: 10.1038/s41467-021-27160-4

Intercellular Arc Signaling Regulates Vasodilation

June Bryan de la Peña, Paulino Barragan-Iglesias, Tzu-Fang Lou, Nikesh Kunder, Sarah Loerch, Tarjani Shukla, Lokesh Basavarajappa, Jane Song, Dominique N. James, Salim Megat, Jamie K. Moy, Andi Wanghzou, Pradipta R. Ray, Kenneth Hoyt, Oswald Steward, Theodore J. Price, Jason Shepherd and Zachary T. Campbell

Journal of Neuroscience 15 September 2021, 41 (37) 7712-7726

doi: 10.1523/JNEUROSCI.0440-21.2021

2020

mRNA stem-loops can pause the ribosome by hindering A-site tRNA binding

C Bao, S Loerch, C Ling, AA Korostelev, N Grigorieff, DN Ermolenko

Elife (2020) May 19:9:e55799.

doi: 10.7554/eLife.55799