Publications

Selected peer-reviewed papers and public preprints from the Loerch Lab.

Preprints

SF3B1 Phosphorylation Prompts U2AF2 Dissociation for Widespread Control of pre-mRNA Splicing

Christopher L. Kirchhoff, Hannah R. Powell, Justin W. Galardi, Sarah Loerch, Mary J. Pulvino, Jermaine L. Jenkins, Paul L. Boutz, and Clara L. Kielkopf

bioRxiv preprint · 2026 · doi: 10.64898/2026.01.19.700466

Separation of halide oxidation and substrate halogenation chemistries rationalizes site-selective vanadium dependent haloperoxidase catalysis

Jackson T. Baumgartner, Lukas A. Varga, Jackson T. Calhoun, Vitor H. Balasco Serrão, Sarah Loerch, and Shaun M. K. McKinnie

bioRxiv preprint · 2025 · doi: 10.1101/2025.10.24.684477

2025

eEF2K regulates pain through translational control of BDNF

Patrick R. Smith, Guadalupe Garcia, Angela R. Meyer, Alexey G. Ryazanov, Tao Ma, Sarah Loerch, and Zachary T. Campbell

Molecular Cell 85(4), 756–769.e5 · published Feb. 20, 2025 · doi: 10.1016/j.molcel.2024.11.023

2023

Protocol for the isolation and culture of mouse dorsal root ganglion neurons for imaging applications

Patrick R. Smith, Angela Meyer, Sarah Loerch, and Zachary T. Campbell

STAR Protocols · doi: 10.1016/j.xpro.2023.102717

2022

Recent advances and current trends in cryo-electron microscopy

Marghe Guaita, Scott C. Watters, and Sarah Loerch

Current Opinion in Structural Biology · doi: 10.1016/j.sbi.2022.102484

In situ single particle classification reveals distinct 60S maturation intermediates in cells

Bronwyn A. Lucas, Kexin Zhang, Sarah Loerch, and Niko Grigorieff

eLife · doi: 10.7554/eLife.79272

A UHM-ULM interface with unusual structural features contributes to U2AF2 and SF3B1 association for pre-mRNA splicing

Justin W. Galardi, Victoria N. Bela, Nazish Jeffery, Xueyang He, Eliezra Glasser, Sarah Loerch, Jermaine L. Jenkins, Mary J. Pulvino, Paul L. Boutz, and Clara L. Kielkopf

Journal of Biological Chemistry · doi: 10.1016/j.jbc.2022.102224

Identifying Inhibitors of −1 Programmed Ribosomal Frameshifting in a Broad Spectrum of Coronaviruses

Sneha Munshi, Krishna Neupane, Sandaru M. Ileperuma, Matthew T. J. Halma, Jamie A. Kelly, Clarissa F. Halpern, Jonathan D. Dinman, Sarah Loerch, and Michael T. Woodside

Viruses · doi: 10.3390/v14020177

The space between notes: emerging roles for translationally silent ribosomes

P. R. Smith, S. C. Pandit, S. Loerch, and Z. T. Campbell

Trends in Biochemical Sciences · doi: 10.1016/j.tibs.2022.02.003

2021

Functionally distinct roles for eEF2K in the control of ribosome availability and P-body abundance

Patrick R. Smith, Sarah Loerch, Nikesh Kunder, Alexander D. Stanowick, Tzu-Fang Lou, and Zachary T. Campbell

Nature Communications · doi: 10.1038/s41467-021-27160-4

Intercellular Arc Signaling Regulates Vasodilation

June Bryan de la Peña, Paulino Barragan-Iglesias, Tzu-Fang Lou, Nikesh Kunder, Sarah Loerch, Tarjani Shukla, Lokesh Basavarajappa, Jane Song, Dominique N. James, Salim Megat, Jamie K. Moy, Andi Wanghzou, Pradipta R. Ray, Kenneth Hoyt, Oswald Steward, Theodore Price, Jason Shepherd, and Zachary T. Campbell

Journal of Neuroscience · doi: 10.1523/JNEUROSCI.0440-21.2021

2020

mRNA stem-loops can pause the ribosome by hindering A-site tRNA binding

C. Bao, S. Loerch, C. Ling, A. A. Korostelev, N. Grigorieff, and D. N. Ermolenko

eLife · doi: 10.7554/eLife.55799